PBPK models describe where a drug goes and how it is eliminated, using the body's real organ volumes, blood flows and clearance pathways. That makes them the tool for questions like drug-drug interactions and dosing in children. Each model is an mrgsolve model and runs in your browser; nothing to install. The first load takes about half a minute while R starts up in the page.
Twelve perfusion-limited tissues with mechanistic partitioning, hepatic and renal clearance, oral absorption, and first-order pediatric scaling with GFR maturation and enzyme ontogeny.
Open the appRifampicin's full PBPK model induces hepatic and intestinal CYP3A; midazolam shows the consequence, and how it wears off after rifampicin stops.
Open the appRifampicin blocks OATP uptake of glibenclamide while present and induces CYP2C9/3A over days, so the interaction flips direction depending on when the victim drug is taken.
Open the appConvective distribution into the interstitial fluid of two tissue groups and lymph return, with optional target-mediated disposition; trastuzumab and ten other antibodies.
Open the appOne drug, two arms: neutralising two cytokines at once, bridging T cells and B cells (mosunetuzumab), and steering a weak therapeutic arm to tumour cells with a strong targeting arm. How CD3 affinity decides how much drug T cells clear.
Open the appWhere infused CAR-T cells go in a tumour-bearing mouse, how many reach the tumour, and how CAR affinity and antigen density together decide whether the tumour is cleared. Affinity saturates: past a point, tighter binding adds nothing.
Open the appEvery model is an mrgsolve model file. Run locally with mrgsolve installed, the apps simulate through mrgsolve. In the browser, the small-molecule model is solved exactly by matrix exponential, and the other models are translated to R and solved with a stiff Rosenbrock solver. The test suite checks each browser engine against mrgsolve, and each model against its published results, before every deployment. Source: github.com/Wrlog/PBPK. For models that add pharmacodynamics and disease biology, see the QSP models.